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Autologous Matrix-Induced Chondrogenesis (AMIC) is a biological treatment option which repairs articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane. AMIC achieves pain relief and restores functionality in the joint with the goal to regain full mobility, allowing going back to previous lifestyle and activity level. It slows down cartilage degeneration with the intent to avoid or delay partial or total joint replacement (e.g. knee replacement) surgery. The initialism AMIC, often used as a genericized trademark, is a registered trademark of Ed. Geistlich Söhne AG, protected by German Registration No. 30255356 and international Registration No. 840373. == Background == The AMIC procedure was first proposed by Behrens in 2003. It aims to extend the use of microfracture surgery to larger cartilage lesions > 2.5 cm2. AMIC is based on microfracturing which relies on the body’s own healing potential. Blood and bone marrow which are released through tiny holes in the subchondral bone plate, fill the damaged cartilage area with a so-called super-clot. This blood clot contains all the elements (e.g. progenitor cells, mesenchymal stem cells (MSCs), cytokines and growth factors) necessary to form new cartilage repair tissue as response to the encountered injury. Adding a collagen membrane to the forming super clot secures it and improves overall clot stability. It also enhances the primary defect fill which is an important parameter for good outcome. Furthermore the application of a collagen membrane provides an environment where cells can adhere, proliferate and produce repair tissue in a protected setting. The originally proposed collagen membrane for AMIC (Chondro-Gide, Geistlich Pharma AG, Switzerland) consists of two sides, two layers (bi-layer design), one dense, compact side and a loose side. Its clinical efficiency in autologous chondrocyte implantation (ACI), another cartilage repair technique for larger cartilage lesions, has been studied extensively. AMIC surgery is currently performed to treat cartilage damage in the knee and in the ankle (talus). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Autologous matrix-induced chondrogenesis」の詳細全文を読む スポンサード リンク
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